1.)As per the Rules for the manufacture, use. import, export & storage of hazardous microorganisms, genetically engineered organisms or cells, 1989 notified under the Environment (Protection)Act, 1986 and as amended from time to time, the Review Committee on Genetic Manipulation (RCGM) shall function in the Department of Biotechnology (DBT) .
2.)RCGM shall monitor the safety related aspects in respect of ongoing recombinant DNA (r-DNA) projects and activities involving Genetically Engineered (GE) organisms/ hazardous microorganisms. All ongoing projects including high risk category and confined field experiments shall be reviewed by RCGM to ensure that adequate precautions and containment conditions are complied with as per the Guidelines and Standard Operating Procedures (SOPs) issued by DBT from time to time.
3.)The RCGM shall lay down procedures restricting or prohibiting production, sale, importation and use of such GE organisms or products thereof for research and applications as mentioned in the schedule of Rules, 1989.
4.)RCGM shall bring out rnanuals and guidelines specifying procedure for regulatory processes with respect to activities involving GE organisms in research, use and application including industry with a view to ensure safety to human, animal and environment health.
5.)The RCGM would issue the clearance letters/permits for import or exchange of genes, DNA fragments, vectors, plasmids, cosmids, etiologic agents and transgenic organisms or germplasm(s) including transformed calli, seeds, plants and plant parts for research use only. It will also take note of all such commercially available agents which are acquired from commercial sources through Institutional Biosafety Committee (lBSC).
6.)The RCGM shall be the regulatory body for receiving and reviewing the applications to conduct confined field trials (such as event selection trials, Biosafety Research Level I trials (BRL-I), pollen flow studies or any other trial involving GE organisms) and recommend appropriate studies to be conducted for data generation for biosafety assessment as per clause 4, as per the decision of the Genetic Engineering Approval Committee (GEAC) for its authorization.
7.)The RCGM, on case-by-case basis, can authorize applicants to use bioreactors to produce sufficient material/end-products of GE organisms required for conducting pre-clinical studies and other relevant data generation including the use of capacity over and above as specified by Recombinant DNA Safety Guidelines, 1990. It will authorize to produce sufficient quantities of GE organism/plant product(s) for generating safety data in appropriate animals as per National and International Guidelines, as appropriate on case-by-case basis.
8.)The RCGM, if required, call generate, examine or invite the research projects, proposals for capacity building and training courses in biosafety, creation of information systems/data banks in electronic media, websites etc. for financial support and recommend the same to DBT for furthering the cause of generating specific biosafety data related to use of GMOs and strengthening infrastructure facilities & dissemination of information on biosafety rules, regulations and guidelines in the country.
9.)The RCGM may also invite, induct or appoint special experts in their individual capacities on a case by case basis.
10.)The RCGM may constitute subgroups of its members or subcommittees involving experts for specific functions or seek advice on specific matters from other external experts.
11.)The RCGM or its constituted subgroups/subcommittees may visit periodically the experimental sites where r-DNA projects and activities involving GE organisms/ hazardous microorganisms are being pursued to ensure that adequate safety measures have been taken as per the guidelines and compliance of SOPs.
12.)The RCGM shall maintain the classified/confidential business information provided by the applicants as confidential.
13.)The RCGM shall function for a period of three years from the date of notification.
14.)The RCGM shall meet once in a month or as and when required.
15.)The members of RCGM shall be paid TA/DA and honorarium as per the Government of India rules as applicable from time to time.